Shakespeare was the son of John Shakespeare, an alderman and a successful glover (glove-maker) originally from Snitterfield in Warwickshire, and Mary Arden, the daughter of an affluent landowning family. He was born in Stratford-upon-Avon, where he was baptised on 26 April 1564. His date of birth is unknown, but is traditionally observed on 23 April, Saint George's Day. This date, which can be traced to William Oldys and George Steevens, has proved appealing to biographers because Shakespeare died on the same date in 1616. He was the third of eight children, and the eldest surviving son. John Shakespeare's house, believed to be Shakespeare's birthplace, in Stratford-upon-Avon.

At the age of 18, Shakespeare married 26-year-old Anne Hathaway. The consistory court of the Diocese of Worcester issued a marriage licence on 27 November 1582. The next day, two of Hathaway's neighbours posted bonds guaranteeing that no lawful claims impeded the marriage. The ceremony may have been arranged in some haste since the Worcester chancellor allowed the marriage banns to be read once instead of the usual three times, and six months after the marriage Anne gave birth to a daughter, Susanna, baptised 26 May 1583. Twins, son Hamnet and daughter Judith, followed almost two years later and were baptised 2 February 1585. Hamnet died of unknown causes at the age of 11 and was buried 11 August 1596.

Although no attendance records for the period survive, most biographers agree that Shakespeare was probably educated at the King's New School in Stratford, a free school chartered in 1553, about a quarter-mile (400 m) from his home. Grammar schools varied in quality during the Elizabethan era, but grammar school curricula were largely similar: the basic Latin text was standardised by royal decree,[23][24] and the school would have provided an intensive education in grammar based upon Latin classical authors.

Shakespeare's career jump-started in London, but when did he go there? We know Shakespeare's twins were baptised in 1585, and that by 1592 his reputation was established in London, but the intervening years are considered a mystery. Scholars generally refer to these years as ‘The Lost Years’.

During his time in London, Shakespeare’s first printed works were published. They were two long poems, 'Venus and Adonis' (1593) and 'The Rape of Lucrece' (1594). He also became a founding member of The Lord Chamberlain’s Men, a company of actors. Shakespeare was the company's regular dramatist, producing on average two plays a year, for almost twenty years. He remained with the company for the rest of his career, during which time it evolved into The King’s Men under the patronage of King James I (from 1603). During his time in the company Shakespeare wrote many of his most famous tragedies, such as King Lear and Macbeth, as well as great romances, like The Winter’s Tale and The Tempest.

Altogether Shakespeare's works include 38 plays, 2 narrative poems, 154 sonnets, and a variety of other poems. No original manuscripts of Shakespeare's plays are known to exist today. It is actually thanks to a group of actors from Shakespeare's company that we have about half of the plays at all. They collected them for publication after Shakespeare died, preserving the plays. These writings were brought together in what is known as the First Folio ('Folio' refers to the size of the paper used). It contained 36 of his plays, but none of his poetry.

Shakespeare’s legacy is as rich and diverse as his work; his plays have spawned countless adaptations across multiple genres and cultures. His plays have had an enduring presence on stage and film. His writings have been compiled in various iterations of The Complete Works of William Shakespeare, which include all of his plays, sonnets, and other poems. William Shakespeare continues to be one of the most important literary figures of the English language.

Shakespeare’s success in the London theatres made him considerably wealthy, and by 1597 he was able to purchase New Place, the largest house in the borough of Stratford-upon-Avon. Although his professional career was spent in London, he maintained close links with his native town. Recent archaeological evidence discovered on the site of Shakespeare’s New Place shows that Shakespeare was only ever an intermittent lodger in London. This suggests he divided his time between Stratford and London (a two or three-day commute). In his later years, he may have spent more time in Stratford-upon-Avon than scholars previously thought.

On his father's death in 1601, William Shakespeare inherited the old family home in Henley Street part of which was then leased to tenants. Further property investments in Stratford followed, including the purchase of 107 acres of land in 1602.

Shakespeare died in Stratford-upon-Avon on 23 April 1616 at the age of 52. He is buried in the sanctuary of the parish church, Holy Trinity.